Slime loses connection if new CL is opened which does not have glime loaded, after glime.el is loaded into the emacs
If you do
(load-glime)
this will compile & load glime.lisp
.
If you then
M-x load-file .../glime.el
it will enable the emacs extentions which make completions etc work better in glime.
However if you now spawn a new Lisp from the same Slime/emacs session, e.g. with
M-- M-x slime
and load Gendl on top of it, but without glime loaded, now you will get errors and lose the Slime connection, if you try to edit a Gendl file.